Management of an inherited predisposition to breast cancer.

Copyright © 2007 Massachusetts Medical Society. A healthy 33-year-old woman comes to establish care. She reports no breast symptoms, her age at menarche was 14, and she has no children. She notes a family history of early-onset breast cancer in her sister (whose condition was diagnosed at the age of 35 years and who is alive at 39 years), mother (diagnosed at 37 years and alive at 60 years), and maternal aunt (diagnosed at 42 years and alive at 62 years). Her maternal grandfather died of prostate cancer. What would you advise regarding screening for breast cancer and strategies to reduce her risk?